In this article we reviewed the literature on injuries and their mechanisms in bodybuilders. Bodybuilding is a weightlifting sport where the main goal is to increase muscle mass while maitaining body symmetry. From a biomechanical point of view, it is important to analyse technical performance of exercises to improve sports technique. Compound exercises based on the development of muscle hypertrophy must be included. The training is different before and during season, in pre-season it is based on reduction of body fat to a low level and a high volume of aerobic exercise. Adequate nutrition, use of supplements and banned substances are widespread in the sport. In that case athletes should be very careful for banned substances in accordance with WADA Code. The most commonly performed exercises where injuries happen are the squat, deadlift and benchpress. The majority of injuries (60 %) are acute, with 93 % shoulder joint injuries, 85 % lower back injuries and 80 % knee injuries. The incidence of injuries is low compared to other sports, between 0.24/1000 hours of training or 0.12 injuries per lifter per year. The most common type of injury is muscle strain, followed by tendinitis and cartilage wear. So it is therefore important to identify risk factors to allow the development of appropriate prevention programs. Muscle ruptures are common with high eccentric loads, with pectoralis major tendon being the most vulnerable to be injured. Than followed by a rupture of biceps femoris during the deadlift exercise, during sudden flexion of the hip joint while the knee is extended. Eccentric contraction and rupture also occurs in the quadriceps muscle, which lifters try to avoid by performing low-bar squat. Uncontrolled abdominal pressure during high-weight exercises causes discus hernias, which lifter can prevent by breathing correctly and using strong muscle stabilizers. The most well-known injury of all is elbow burzitis or »Bodybuilders elbow« due to repetitive flexion and extension movements of elbow joint. To prevent this injuries we have to include preventive measures such as medical check-ups, education of athletes, ensuring safety in competitions, appropriate training and load distribution, treating the body as a whole and regular equipment check-ups.