In sprint disciplines, the start reaction (SR) time affects the final result in the sprint. This research aimed to analyze and examine whether there are significant differences in the SR in the semi-final and final groups in the 60 m and 400 m disciplines at the World Indoor Championships in Athletics, held in Belgrade in 2022 in men's and women's competition. The aim was also to determine if there were statistical differences between men and women in the 400 m event. T-test for independent samples showed statistical differences between the SR in the 60 m and 400 m athletics events in men (t=-4.434, p=0.000) and women (t=-3.210, p=0.004). For the 400 m running events, an independent samples t-test was used to examine differences between men and women in SR. No significant differences were obtained between men and women in the 400 m event (t=0.401, p=0.691). SR is part of all running disciplines and affects the time achieved in the race (result). Although it has been known for a long time that training can influence SR, a few studies still examine training's effects on SR. The question can be about how much it is possible to reduce SR with specific training exercises or to apply certain neurophysiological methods.