The present cross-over study investigated whether a half-marathon race might impose changes in lipid profile, muscle function, hematological parameters, and oxidative status in 10 amateur male runners and whether polyphenol-rich aronia juice may counteract these potential alterations.

Subjects (age 30.8 ± 2.3 years) ran a simulated half-marathon race (21.1 km), after they had consumed breakfast with 200 mL of aronia juice/placebo on two occasions separated by one week. Blood samples were taken at baseline, 15 min, 1 h, and 24 h after the run. 

Results revealed a significant increase in the levels of total, LDL cholesterol, and triglycerides immediately after the run (by 6.97%, 9.23%, and 38.46%, respectively), which tended to return to the baseline values after 24 hours. The activity of lactate dehydrogenase increased significantly after the race and started decreasing 24h after the race, still being 16.18% higher compared with the baseline. The run induced a marked increase in total number of leukocytes, and granulocytes, with an eventual return to the baseline levels.

The obtained results suggest that a half-marathon run is intense enough to cause lipid mobilization, muscle damage and compromise the immune response in recreational male runners. Acute aronia juice intake was not sufficient to attenuate the observed changes.